Preventive Use of Common Antibiotic Reduces Child Mortality in Sub-Saharan Africa
Treating young children in Sub-Saharan Africa with azithromycin, a safe, inexpensive, and widely used antibiotic, significantly reduced deaths of children under five.
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Fetal Immune System Rejects the Mother in Preterm Labor
A new study from UCSF shows preterm labor may sometimes happen when the fetal immune system “wakes up” too early and begins to reject the mother, causing the uterus to start contracting.
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HIV Begins to Yield Secrets of How It Hides in Cells
UCSF scientists have uncovered new mechanisms by which HIV hides in infected cells, resting in a latent state that evades the body’s immune system and preventing antiviral drugs from flushing it out.
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USAID Awards Global Malaria Contract to UCSF's Malaria Elimination Initiative and Partners
The MEI is part of a group of partners that has been awarded a new contract by USAID to support the President’s Malaria Initiative’s Advancing the Progress of Malaria Service Delivery project in 28 countries.
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Cancer-Killing Virus Acts by Alerting Immune System
A new UCSF study has shown that a cancer-killing (“oncolytic”) virus currently in clinical trials may function as a cancer vaccine.
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Study Points to Immune System’s Role in Neural Development
A new study shows that an immune signal named interleukin 33 plays a crucial role in allowing the brain to maintain the optimal number of synapses during the development of the central nervous system.
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New Immunotherapy for Deadly Childhood Brain Cancer Targets Novel 'Neoantigen'
Children with an extremely deadly form of brain cancer might benefit from a new treatment that aims to direct an immune response against a mutant form of a protein found exclusively on cancer cells.
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UCSF Specialties Among World’s Best in US News Global Universities Rankings for 2018
UCSF has ranked in the top 10 for seven specialties in 2017 Best Global Universities rankings released Tuesday by U.S. News & World Report.
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Allergy Drug Improves Function in Patients with Chronic Injury from Multiple Sclerosis
UCSF scientists have successfully completed a Phase II clinical trial showing that an FDA-approved antihistamine restores nervous system function in patients with chronic MS.
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3-D Imaging Reveals Secrets of Immune Cells’ Agility
Newly developed microscopy techniques have allowed UC San Francisco researchers to observe white blood cells in action in unprecedented detail.
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Gut Microbes May Influence Multiple Sclerosis Progression
Researchers at UCSF have identified specific gut microbes associated with MS in human patients, showing that these microbes take part in regulating immune responses in mouse models of the disease.
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Gut microbes could help trigger multiple sclerosis
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Gut germs play role in multiple sclerosis, studies show. Are probiotics for MS next?
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Blunting CRISPR’s ‘Scissors’ Gives New Insight into Autoimmune Disorders
Research team led by University of California scientists has used a modified version of the gene-editing technique CRISPR to find enhancers by prompting them into action.
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Gut Feeling for Probiotics Benefits May Be Overstated, UCSF Study Shows
A study headed by UCSF researchers fuels the probiotics debate by finding that there is no clear evidence that a supplement of the “friendly” bacteria strain of lactobacillus prevents eczema.
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Gut Viruses Tied to Potentially Deadly Complication of Bone Marrow Transplant
A virus hiding quietly in the gut may trigger the onset of a severe complication known as graft-versus-host disease (GvHD) in patients who receive bone marrow transplants.
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Immune-Cell Numbers Predict Response to Combination Immunotherapy in Melanoma
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study.
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Brain’s Immune Cells May Drive Overeating and Weight Gain
Immune cells in the brain trigger overeating and weight gain in response to diets rich in fat, according to a new study in mice led by researchers from UCSF and the UW Medical Center.
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New Hair Growth Mechanism Discovered
In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells, directly trigger stem cells in the skin to promote healthy hair growth.
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Video Imaging Reveals How Immune Cells Sense Danger
How T cells feel out intruders rapidly and reliably enough to nip infections and other threats in the bud has remained a mystery to researchers.
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New Polio Virus Evolution Insights Could Lead to Improved Vaccine
UCSF researchers have helped to identify the three evolutionary steps the polio virus used to evolve from harmless vaccine into a regional menace. With the new knowledge, they have developed a new polio vaccine that should be unable to escape and cause outbreaks.
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Successful Immunotherapy Requires System-Wide Immune Response
New research has found that successful cancer immunotherapy appears to depend on whether the treatment can trigger a system-wide immune response, rather than just a local response within the tumor itself.
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New ‘Immunoprofiler’ Initiative will Advance Drug Discovery, Precision Immunotherapy for Cancer
UC San Francisco scientists have formed an innovative research alliance with three global pharmaceutical companies.
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Positive Multiple Sclerosis Clinical Trial Results Support New Treatment Approach
In findings that show the effectiveness of a new strategy for treating multiple sclerosis, researchers are reporting positive results from three large, international, multicenter Phase III clinical trials of the investigational drug ocrelizumab in both relapsing multiple sclerosis and primary progressive multiple sclerosis.
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Research Cracks Genetic Driver of Patient’s Rare Immune Disorder
UCSF-led research team identified the rare genetic mutation responsible for a unique case of severe combined immunodeficiency, a deadly immune system disorder also known as “boy in the bubble” disease.
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Science in Focus: Evolving Immune Fighters in the Gut
Graduate student Lauren Rodda captured a microscopic mage of a mouse gut, which highlights her work to understand the germinal center, where immune cells compete to be the best at recognizing an invading pathogen.
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Researchers Use CRISPR to Accelerate Search for HIV Cure
Researchers at UCSF and the academically affiliated Gladstone Institutes have used a newly developed gene-editing system to find gene mutations that make human immune cells resistant to HIV infection.
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UCSF in Top 20 for U.S. News’ 2017 Global Universities Rankings
UCSF has ranked as one of the top 20 universities in the world, according to the 2017 Best Global Universities rankings released Tuesday by U.S. News & World Report.
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How a School of Dentistry Lab Joined Fight Against Zika
Lenore Pereira, a virologist and professor in School of Dentistry’s Department of Cell and Tissue Biology, is in the middle of crucial research to understand how the mosquito-borne Zika virus harms the babies of women infected during pregnancy.
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Replacing Myelin Protects Nerve Cells, Restores Function in Mouse Model of Multiple Sclerosis
Using a mouse model of multiple sclerosis, UCSF scientists demonstrated that regenerating myelin can both protect neurons from damage and restore lost function.