University of California San Francisco
Give to UCSF
A new study is the first to show that while the impact of life’s stressors accumulate over time and accelerate cellular aging, these negative effects may be reduced by maintaining a healthy diet, exercising and sleeping well.
Researchers at UCSF have discovered that endostatin, a protein that once aroused intense interest as a possible cancer treatment, plays a key role in the stable functioning of the nervous system.
In a new study led by UCSF scientists, a chemical compound designed to precisely target part of a crucial cellular quality-control network provided significant protection, in rats and mice, against degenerative forms of blindness and diabetes.
There are 100 trillion bacterial cells living in and on our bodies. In the spring issue of UCSF Magazine, find out how these bacteria could be the key to treating and preventing a number of conditions from asthma to obesity.
UCSF scientists have shown that cancer-induced structural changes in a sugary coating ensheathing cells can promote mechanical interactions that fuel tumor growth and metastasis.
A team of researchers studying a flowering plant has zeroed in on the way cells manage external signals to adapt to prevailing conditions, a capability that is essential for cells to survive in a fluctuating environment.
The calorie-burning triggered by cold temperatures can be achieved biochemically – without the chill – raising hopes for a weight-loss strategy focused on the immune system rather than the brain, according to a new UCSF study.
The New York Times Health for Tomorrow conference, held at UCSF, featured experts from the University of California and across the country, addressing the changing landscape of health care.
UCSF's Peter Walter has received Asia’s highest scientific honor, the 2014 Shaw Prize in Life Science and Medicine, for his groundbreaking discovery of a cellular system that makes “life and death decisions” for the cell.
UCSF cell biologist Torsten Wittmann, PhD, has just made a key discovery of a molecular process that is a lynchpin in permitting the directional movement of cells.
The stiffening of breast tissue in breast-cancer development points to a new way to distinguish a type of breast cancer with a poor prognosis from a related, but often less deadly type, UCSF researchers have found in a new study.
Scientists at the Gladstone Institutes and UCSF have made an important breakthrough: they have discovered a way to transform skin cells into mature, fully functioning liver cells that flourish.
Researchers are harnessing the power of the body's natural defenses to fight deadly cancers, and the treatment appears to be powerful, effective and long-lasting.
In a finding that directly contradicts the standard biological model of animal cell communication, UCSF scientists have discovered that typical cells in animals have the ability to transmit and receive biological signals by making physical contact with each other, even at long distance.
Research led by scientists at the UCSF-affiliated Gladstone Institutes has identified the precise chain of molecular events in the human body that drives the death of most of the immune system’s CD4 T cells as an HIV infection leads to AIDS. Further, they have identified an existing anti-inflammatory drug that in laboratory tests blocks the death of these cells.
Scientists at the UCSF-affiliated Gladstone Institutes have devised a new molecular sensor that can detect MS at its earliest stages, even before the onset of physical signs.
In a technical tour de force, UCSF scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.
The protein in cells that most often drives the development of cancers has eluded scientists’ efforts to block it for three decades — until now.
Current anti-obesity treatments include strategies to prevent food energy from being absorbed, such as orlistat, which prevents fat absorption from food.
Researchers at the UCSF-affiliated Gladstone Institutes have discovered how the activation of specific stretches of DNA control the development of uniquely human characteristics.
UCSF scientists were able to arrest, and even reverse, tissue scarring of the liver, kidneys and lungs in mice. The scarring, also known as fibrosis, is a major factor in nearly half of all deaths in developed countries.
When it comes to genes, a UCSF scientist wants to turn conventional wisdom about human and bacterial evolution on its head.
Through support from the Catalyst Awards, UCSF researcher Aditi Bhargava is working to develop a method for delivering small-molecules to a specific target group of cells for treatment of pain.
The way cells divide to form new cells – to support growth, to repair damaged tissues, or simply to maintain our healthy adult functioning – is controlled in previously unsuspected ways, UCSF researchers have discovered.
UCSF researchers received six of 78 awards announced this week by the National Institutes of Health for innovative, high-risk, high-reward research.
A new link between meal times and daily changes in the immune system has been identified by UCSF researchers, and has led them to question assumptions about the roles of specific immune cells in infection and allergy.
A protein at the center of Parkinson’s disease research now also has been found to play a key role in causing the destruction of bacteria that cause tuberculosis.
Quick changes in behavior, in worms, at least, can be triggered by a unique form of the molecule RNA acting within the nucleus of a cell, researchers at UCSF have discovered.
UCSF scientists working in the lab used a chemical found in an anti-wrinkle cream to prevent the death of nerve cells damaged by mutations that cause an inherited form of Parkinson’s disease.
Researchers have probed deep into the cell’s genome to begin learning the “grammar” that helps determine whether or not a gene gets switched on to make the protein it encodes, advancing efforts to use gene and cell-based therapies to treat disease.