Prostate Cancer Disparities Greatest in Low-Risk Disease
Study, led by UCSF, raises intriguing questions about whether the biology of low-risk prostate cancer in black men is distinct from that of other ethnicities.
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Most Popular Science Stories of 2018
From sensory processing disorder to how CRISPR is being explored to bring new treatments to patients, these are the stories that most engaged our readers in 2018.
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Depression, Anxiety May Take Same Toll on Health as Smoking and Obesity
Anxiety and depression may be leading predictors of conditions ranging from heart disease to headaches, having similar effects as long-established risk factors like smoking and obesity.
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Cancer Researchers ID ‘Achilles Heel’ of Drug-Resistant Tumors
UCSF scientists have figured out why some lung cancers become drug-resistant after initially responding to targeted therapies.
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New ‘SLICE’ Tool Can Massively Expand Immune System’s Cancer-Fighting Repertoire
UCSF researchers have devised a CRISPR-based system called SLICE, which will allow scientists to rapidly assess the function of each and every gene in “primary” immune cells.
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Treating Brain Cancer with Radiation May No Longer Imperil Cognition
Using a mouse model, researchers showed that a drug that temporarily suppresses a key component of the brain’s immune system can prevent radiation-associated cognitive decline.
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Less Surveillance Needed for Simple Ovarian Cysts
Study found that simple cysts are normal, extremely common and aren’t linked to a higher risk of ovarian cancer. As a result, unless they are symptomatic, simple cysts can be safely ignored.
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‘Orphan’ RNAs Make Cancer Deadlier, But Potentially Easier to Diagnose
UCSF demonstrates that cancer is a clever engineer, capable of constructing entirely new disease-promoting networks out of raw materials readily available in the cell.
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With Disease Agnostic Approach, QBI is Accelerating Ambitious Science
The Quantitative Biosciences Institute attracts investigators on the basis of the tools and techniques they employ, rather than the diseases they study.
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Advanced Skin Cancer Was Once a Death Sentence. Immunotherapy Is Changing That
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Heated Tobacco Product Claims by Tobacco Industry Scrutinized by UCSF Researchers, Others in Independent Data Review
Claims by the tobacco industry that heated tobacco products (HTPs) are safer than conventional cigarettes are not supported by the industry’s own data and are likely to be misunderstood by consumers.
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Blood Test ‘Biopsy’ for Kids with Brain Tumors Is Simple, Safe Way to See If Treatment Is Working
A new blood test for children with brain tumors offers a safer approach than surgical biopsies and may allow doctors to measure the effectiveness of treatment even before changes are identified on scans.
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Building a Patchwork Brain to Study Neurological Disease
Scientists at UCSF and Boston Children’s Hospital have developed a new technique for making mice with brains that combine the genetics of two different mouse strains.
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Talk on ‘Butt Cancer’ Tackles Taboo with Humor to Win 2018 Postdoc Slam
Ten UCSF postdocs competed to explain complex research in simple language – and in three minutes or less – in the third annual Postdoc Slam held Sept. 26.
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Present at Creation of Nobel-Winning ‘Checkpoint Inhibitor’ Therapies, Immunologist Looks to the Future
UCSF’s Max Krummel was a graduate student in the laboratory of Nobel Prize winner James P. Allison, PhD. Now Krummel is leading an ambitious project at UCSF to expand immunology and immunotherapy to understand and potentially treat new diseases.
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UCSF Receives $20 Million to Study New Tobacco Products
UCSF has been awarded a five-year, $20 million grant from the U.S. Food and Drug Administration and the National Institutes of Health to study the impacts of new and emerging tobacco products.
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HPV and Tobacco Induce Cancer Through Common Pathways
These results confirm that the HPV virus causes head and neck cancer by inactivating the same proteins that are mutated in smoking-induced cancer.
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Researchers Unlock Secret of Deadly Brain Cancer’s “Immortality”
UCSF researchers have discovered how a mutation in a gene regulator called the TERT promoter confers “immortality” on tumor cells, enabling the unchecked cell division that powers their aggressive growth.
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Mutations, Drugs Drive Cancer by Blurring Growth Signals
Genetic mutations in a form of non–small cell lung cancer may drive tumor formation by blurring cells’ perception of key growth signals, according to a new laboratory study published Aug. 31, 2018, in Science.
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Tailored Drug Cocktails Offer Hope to Kids with Aggressive Brain Tumors
By creating a tailored drug cocktail that matches the mutations of a brain tumor, a new precision medicine approach may move the needle for children with high-grade gliomas.
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Breast Cancer Surgery in Frail Elderly Women Linked to Poor Results
UCSF researchers found that 58 percent of women who resided in a nursing home for more than 90 days before breast cancer surgery experienced significant functional decline one year after surgery.
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Chronic Inflammation Can Trigger Cancers Via Newly Discovered Mechanism
In these patients, chronic tissue inflammation causes an over-active protein to introduce mutations across the genome, some of which eventually lead to cancer.
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Risk of Heart Attacks is Double for Daily E-Cigarette Users
Use of e-cigarettes every day can nearly double the odds of a heart attack, according to a new analysis of a survey of nearly 70,000 people, led by researchers at UCSF.
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‘Undruggable’ Cancers Slowed by Targeting Growth Signals
Researchers have identified a new strategy for potentially treating a subset of intractable cancers by decoupling the entire RAS / MAP Kinase signaling pathway from external growth signals.
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Important Cancer-Tracking Registry to Locate at UCSF
The Greater Bay Area Cancer Registry, which has been at the forefront of cancer data collection throughout the region is moving its headquarters and management to UCSF.
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Genetic Study of Familial Leukemia Solves 30-Year Medical Mystery
A decades-old medical mystery has been solved by researchers at UCSF and St. Jude Children’s Research Hospital in Tennessee, who have discovered a pair of inherited genetic mutations underlying a familial blood disorder that sometimes leads to leukemia.
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CRISPR-Based Tool Maps Gene Function in Human Cells
UCSF scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
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Genomic Landscape of Metastatic Prostate Cancer Unveiled in New Study
A comprehensive genetic analysis of metastatic prostate cancer has, for the first time, revealed a number of major ways in which abnormal alterations of the genome propel this aggressive form of the disease.
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Breast Cancer Follow-Up Imaging Varies Widely, Study Finds
Follow-up imaging for women with non-metastatic breast cancer varies widely across the country, according to a new study led by researchers at UCSF.
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T Cell Engineering Breakthrough Sidesteps Need for Viruses in CRISPR Gene-Editing
In an achievement that has significant implications for research, medicine, and industry, UCSF scientists have genetically reprogrammed human immune cells without using viruses to insert DNA
