3 Ways Viruses Have Changed Science for the Better
A virus is nature’s efficient little killer. They’re really good at what they do, and we’ve been able to harness their skills to learn about – and potentially improve – human health in several ways.
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‘Remote Control’ of Immune Cells Opens Door to Safer, More Precise Cancer Therapies
UCSF researchers have engineered a molecular “on switch” that allows tight control over the actions of T cells, immune system cells that have shown great potential as therapies for cancer.
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Building Human Breast Tissue, Cell by Cell
Zev Gartner is working to building a fully functioning 3-D human breast tissue that will allow him to test potential cancer therapies, an innovation that's earned him a spot among Popular Science's "Brilliant 10" this year.
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Childhood Cancer Research at UCSF to Transcend Tissue Types With Innovative Grant
Researchers at UCSF are leading a five-year, $10 million research project dedicated to pediatric cancer, funded by the first grant of its kind to focus on a molecular pathway that underlies many cancers.
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UCSF Researchers Control Embryonic Stem Cells With Light
UCSF researchers have for the first time developed a method to precisely control embryonic stem cell differentiation with beams of light, enabling them to be transformed into neurons in response to a precise external cue.
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In CRISPR Advance, Scientists Successfully Edit Human T Cells
In a project spearheaded by investigators at UCSF, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
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Age-Related Cognitive Decline Tied to Immune-System Molecule
A blood-borne molecule that increases in abundance as we age blocks regeneration of brain cells and promotes cognitive decline, suggests a new study.
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Cancer Blocked by Halving Levels of Protein Thought To Be ‘Untouchable’
A team of UC San Francisco and Stanford University scientists has discovered that a protein thought to be crucial for the body to develop and function correctly can be reduced by half in mice with no apparent ill effects.
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Specific Roles of Adult Neural Stem Cells May Be Determined Before Birth
Adult neural stem cells, which are commonly thought of as having the ability to develop into many type of brain cells, are in reality pre-programmed before birth to make very specific types of neurons.
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The Resolution Revolution: Building a Better Microscope to See at the Atomic Level
After decades of challenges, scientists have developed an imaging technique that allows them to see the detailed structure of tiny proteins — and it's changing how we think about medicine.
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Evolution of Stem Cells Traced in Study of Fossilized Rodent Teeth
By studying fossilized teeth from thousands of extinct rodent species, UCSF and University of Helsinki scientists have shown how fundamental evolutionary mechanisms drive the emergence of novel mammalian stem cells.
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Childhood Syndrome Combining Lung Disease, Arthritis Is Identified
A research team led by scientists from UCSF, Baylor College of Medicine, and Texas Children’s Hospital has identified a new autoimmune syndrome characterized by a combination of severe lung disease and arthritis that currently has no therapy.
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Angiogenesis Inhibitors Undermined by Immune Cells, Says Study
A team led by UCSF scientists has discovered a possible reason why angiogenesis inhibitors often work in the short term but usually become ineffective within months, one that could lead to a way to prevent cancer relapse.
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First Look at ‘Wasabi Receptor’ Brings Insights for Pain Drug Development
Researchers at UCSF have pulled aside the curtain on a protein informally known as the “wasabi receptor,” revealing at near-atomic resolution structures that could be targeted with anti-inflammatory pain drugs.
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How Beige Fat Could Fight Obesity
For the first time, scientists have isolated beige fat in adult humans that's able to convert energy-storing white fat cells into the energy-burning kind.
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UMass Dartmouth, UCSF Research Demonstrates Shared Rules of Development Can Predict Patterns of Evolution in Different Species
The evolution and development of structures as diverse as limbs, fingers, teeth, somites and vertebrae may have more in common than once believed, according to a new study.
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Researchers Identify “Beige” Fat-Burning Cells in Humans
A research team, led by a UCSF biologist, has isolated energy-burning “beige” fat from adult humans, which is known to be able to convert unhealthy white fat into healthy brown fat.
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Calico Licenses Technology from Acclaimed UCSF Laboratory
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To Beat Leukemia, Boost Cell Signaling, Study Suggests
A new study of acute lymphoblastic leukemia led by UCSF researchers puts an intriguing new twist on anti-cancer strategies.
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Protein May Be Key to Cancer’s Deadly Resurgences
New research finds a special protein may control the survival of deep, near-dormant cancer cells that allow tumors to regrow even after other cells have been eradicated.
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‘Most Comprehensive Map’ of Human Epigenomes Is Unveiled
Two dozen scientific papers published online simultaneously present the first comprehensive maps and analyses of the epigenomes of a wide array of human cell and tissue types.
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Study Shows Why Some Targeted Cancer Drugs Lose Effectiveness
A protein called YAP, which drives the growth of organs during development and regulates their size in adulthood, plays a key role in the emergence of resistance to targeted cancer therapies, according to a new study.
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UCSF Team Finds Biochemical Key to Feeding Behavior
Researchers at UCSF have identified the chemical that signals to roundworms when they are hungry, the same chemical implicated in several neurodegenerative disorders. The finding may provide useful clues for understanding and treating these disorders.
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The 'Oddball Organism' that Helped Win a Nobel Prize
Meet the Tetrahymena, the pear-shaped protozoa that played a starring role in Nobel Prize-winning research about aging.
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Top Trends in Health and Science for 2015
With advances in technology and better understanding of people, the health sciences are constantly pushing toward more effective treatments and cures. The question is, where will we see the next breakthroughs in 2015?
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Precise Control Over Genes Results from Game-Changing Research
The application of a new, precise way to turn genes on and off within cells is likely to lead to a better understanding of diseases and possibly to new therapies, according to UCSF scientists.
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Our Microbes Are a Rich Source of Drugs, UCSF Researchers Discover
Bacteria that normally live in and upon us have genetic blueprints that enable them to make thousands of molecules that act like drugs, and some of these molecules might serve as the basis for new human therapeutics, according to UCSF researchers.
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Peter Walter’s Career of ‘Challenging the Unknown’ Leads to Lasker Award
Peter Walter has won the 2014 Lasker Award, popularly known as the "American Nobels." It’s the second major accolade this year alone for the Germany native, whose career didn't always point toward being a research scientist.
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UCSF Professor Peter Walter Receives Lasker Award for Basic Research
Peter Walter, PhD, professor of biochemistry and biophysics at UCSF, has received the 2014 Lasker Basic Medical Research Award.
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Cancer Categories Recast in Largest-Ever Genomic Study
New research partly led by UCSF-affiliated scientists suggests that one in 10 cancer patients would be more accurately diagnosed if their tumors were defined by cellular and molecular criteria rather than by the tissues in which they originated.
