Altruistic Viruses? Phages Fight Back Against CRISPR Defenses In Bacteria
Although CRISPR has made headlines as a powerful system for editing genes, it actually evolved as way for bacteria to defend themselves against infection by viruses.
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Gut's 'Taste Buds' Help School the Immune System in the Thymus
UCSF researchers discovered fully formed gut and skin cells in the thymus, the organ responsible for training the T cells of the immune system not to attack the body’s own tissues.
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Breast Cancer Follow-Up Imaging Varies Widely, Study Finds
Follow-up imaging for women with non-metastatic breast cancer varies widely across the country, according to a new study led by researchers at UCSF.
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UCSF Study Finds Simplified Systems Intervention Improves Blood Pressure Control in Safety-Net Settings
Study shows that a simplified intervention building on the hypertension treatment algorithm used in KP’s PHASE program can significantly improve rates of blood pressure control in the city’s safety net clinics.
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T Cell Engineering Breakthrough Sidesteps Need for Viruses in CRISPR Gene-Editing
In an achievement that has significant implications for research, medicine, and industry, UCSF scientists have genetically reprogrammed human immune cells without using viruses to insert DNA
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Hospital Quality Improves Over Time with EHRs, Study Finds
An examination of how the adoption of EHRs affected the quality of hospital care between 2008 and 2013 found that mortality rates fell as hospitals learned how to work with the technology.
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Deadly Form of Advanced Prostate Cancer is Common, Calls for Distinct Treatment
Study of prostate cancer in 202 men, whose cancers had spread and were resistant to standard treatment, found that about 17 percent of these cancers belong to a deadlier subtype of metastatic prostate cancer.
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Evolution of Melanoma Reveals Opportunities for Intervention
UCSF researchers have identified the sequence of genetic changes that transform benign moles to into malignant skin cancer.
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How CRISPR Tools are Unlocking New Ways to Fight Disease
The already famous CRISPR system allows scientists to edit faulty genes by cutting and replacing sections of DNA, but new and improved CRISPR techniques developed at UCSF have expanded CRISPR’s scalpel into a Swiss Army knife.
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New Form Of Wound Healing Revealed By Parasitic Gut Worms
Experiments using parasitic worms in the mouse gut have revealed a surprising new form of wound repair, a finding that could help scientists develop ways to enhance the body’s natural healing abilities.
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FDA Approves Landmark Marijuana-Derived Drug First Tested at UCSF
For the first time, a drug derived from marijuana has been approved by the Food and Drug Administration, and it may soon offer relief to children with hard-to-treat seizures.
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Do Dreams Prevent Atrial Fibrillation?
UCSF research team found that having less REM sleep – the sleep that includes more dreaming – was linked to higher chances of developing AF.
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‘Music of Speech’ Linked to Brain Area Unique to Humans
Insights into pitch control could pave the way for advanced brain prosthetics that could allow people who can’t speak to express themselves in a naturalistic way.
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Combination Therapy May Revive Prospects for ‘Embattled’ Breast Cancer Drugs
Researchers identified a protein that cancer cells use as a shield to protect the PI3K pathway against targeted drugs, and showed that blocking this protein allowed previously ineffective therapies to slow cancer cell growth and shrink tumors.
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Immune Profile for Successful Cancer Immunotherapy Discovered
UCSF researchers have identified a key biological pathway in human cancer patients that appears to prime the immune system for a successful response to immunotherapy drugs – checkpoint inhibitors.
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Health Hub Launches in Collaboration with UCSF
UCSF and a newly formed, next-generation nonprofit organization, Health Hub, are announcing their plans to affiliate.
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Prop. 47 Lessened Racial Disparities in Drug Arrests
UCSF researchers quantified the effects of Prop 47, which reclassified drug possession offenses from felonies or “wobblers”.
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Not Junk: ‘Jumping Gene’ is Critical for Early Embryo
A so-called “jumping gene” that researchers long considered either genetic junk or a pernicious parasite is actually a critical regulator of the first stages of embryonic development.
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CryoEM Study Captures Opioid Signaling in the Act
Scientists have used ultra-high-resolution cryo–electron microscopy to capture the most detailed portrait ever of an opioid drug triggering the biochemical signaling cascade that gives it its power.
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Deaths from Cardiac Arrest Are Misclassified, Overestimated
Forty percent of deaths attributed to cardiac arrest are not sudden or unexpected, and nearly half of the remainder are not arrhythmic – the only situation in which CPR and defibrillators are effective.
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Electrically Stimulating the Brain May Restore Movement After Stroke
UCSF scientists have improved mobility in rats that had experienced debilitating strokes by using electrical stimulation to restore a distinctive pattern of brain cell activity associated with efficient movement.
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Diabetes Added to High Risks for People with Severe Mental Illness
People with severe mental illness are more than twice as likely to have Type 2 diabetes, with even higher risks among patients who are African American or Hispanic, according to a new study led by UCSF.
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Opioid Crisis: This Doctor’s Street-Level Views Could Change the Course of the Epidemic
A staggering 64,000 people in the United States died in 2016 from drug overdoses – and a study led by UCSF’s Daniel Ciccarone is aiming to get at the heart of of the problem, including by interviewing opioid users.
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NPR’s Nerdette: “I Have A Rare Genetic Disease. CRISPR Might Fix It.”
As a kindergartener, Nerdette co-host Greta Johnsen was diagnosed with an eye condition that is among the best diseases for experimenting with the gene editing tool CRISPR. This episode follows Greta, her father, and UCSF geneticist and Gladstone Institutes investigator Bruce Conklin, MD, as he tries to develop the perfect CRISPR system to remove the faulty DNA from Johnsen’s eye cells.
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Frequent Use of the ER Fell After the Affordable Care Act
The odds of being a frequent user of California’s emergency departments dropped in the two years following the implementation of major provisions of the Affordable Care Act in January 2014.
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Binging, Purging and Fasting More Common in Overweight, Obese Young Adults
Young adults who are overweight or obese are twice as likely as their leaner peers to binge and purge, use laxatives or diuretics, or force themselves to vomit as a means of controlling their weight.
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Startup Science
Silicon Valley is helping researchers like Wendell Lim move basic science breakthroughs into translational applications, making treatments available to patients faster than normally possible.
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2018: A Drug Odyssey
The journey from discovering and developing effective, precise medications to using them correctly and safely in patients is hardly fast and easy. Nor is it a straight shot. Scientists in the UCSF School of Pharmacy are challenging the status quo every step of the way.
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Streets of Pain
UCSF public health researcher Daniel Ciccarone, MD, shares his quest to understand the nation’s opioid epidemic, one user at a time.
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Electric ‘Sixth Sense’ Evolved Differently in Sharks and Skates
UCSF researchers have discovered that shark and skate electrosensory systems have distinct specializations that match how the animals use their electrical sense in the wild.
