Novel Structure Found in Tumor Cells May Open Door to New Kinds of Cancer Therapies
UCSF researchers have figured out precisely what receptor tyrosine kinases are, how they form and their role in cancer.
University of California San Francisco
Give to UCSF
Displaying 121 - 150 of 421
-
-
Cancer Patients Lonely and Depressed During COVID-19 Pandemic
Loneliness and social isolation have been significant problems for the general population during the COVID-19 pandemic, but for cancer patients these issues were particularly acute, likely due to isolation and social distancing, according to a new UCSF study.
-
Smart Cell Therapies for Solid Cancers Ready to Move Toward Clinical Trials
Researchers at UCSF have demonstrated how to engineer smart immune cells that are effective against solid tumors, opening the door to treating a variety of cancers that have long been untouchable with immunotherapies.
-
New Technique Maps Cell Locations, Hinting at Their Roles
-
First of Its Kind Study Links Wildfire Smoke to Skin Disease
A new study suggests that the dangers posed by wildfire smoke may also extend to the largest organ in the human body, and our first line of defense against outside threat: the skin.
-
Deaths Rising in Workers Using Methylene Chloride Paint Strippers
The study is the first comprehensive review of fatalities linked to the deadly chemical in the United States and identified more deaths than previously reported.
-
Pancreatic Cancer Cells Hijack Muscle Protein to Beef Up Their Metabolism
Cancer starts with mutations in a cell’s DNA, but new UCSF research shows that the endurance of a tumor relies on its ability to rapidly evolve and adapt to challenges brought about by the environment in which it grows.
-
Store Fat or Burn It? Targeting a Single Protein Flips the Switch
UCSF researchers found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet.
-
Podcast: How a Fascination with Saliva Helped Solve a Health Crisis
Tissue biologist Sarah Knox has long been fascinated with saliva. Just when she begins to doubt whether her singular passion will lead to real-world impact, an old family friend reaches out to her with a problem only she may be able to solve.
-
New Test Predicts Tumors Most Likely to Respond to Radiation, Chemotherapy
Many cancer patients might respond better to treatments with the help of a new prognostic indicator based on a distinctive pattern of gene activity within tumor cells.
-
Response to Cancer Immunotherapy May Be Affected by Genes We Carry from Birth
A new study finds that inherited genetic variation plays a role in who is likely to benefit from checkpoint inhibitors, which release the immune system’s brakes so it can attack cancer.
-
‘Invisible’ Stem Cells Evade Natural Killer Cells Using Immune ‘Off-Switch’
UCSF scientists have discovered a new way to control the immune system’s “natural killer” cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection.
-
Novel Tool Deciphers Cells’ Energetic Code to Enhance Anticancer Therapies
Immunotherapies are a promising anticancer arsenal and work by mobilizing the immune system to recognize and destroy cancer cells. Currently, however, only a third of patients respond to
-
Big Data Powers Design of ‘Smart’ Cell Therapies for Cancer
Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research.
-
Breast Cancer Study Hits 30K Milestone in Demystifying Risk
A new, $9 million grant from the National Cancer Institute to increase ethnic diversity will help the study work toward a goal of enrolling 100,000 or more women overall.
-
Climate Change Will Give Rise to More Cancers
Climate change will bring an acute toll worldwide, with rising temperatures, wildfires and poor air quality, accompanied by higher rates of cancer, especially lung, skin and gastrointestinal cancers.
-
Axing the ACA Means Young Adults with Cancer Lose Coverage
Researchers found that patients with a pediatric cancer who were protected under the ACA’s dependent coverage provision were more likely to remain on private insurance for longer durations compared to their older peers who turned 19 before the Act.
-
Risk of Deadly Skin Cancer May Be Gauged by Accumulated DNA Damage
Risk for melanoma, the most deadly skin cancer, can be estimated long before detection of any suspicious moles, according to a UCSF scientist.
-
Cancer Immunotherapy ‘Uniquely Suppressed’ by Liver Tumors
Though cancer immunotherapy has become a promising standard-of-care treatment – and in some cases, perhaps a cure – for a wide variety of different cancers, it doesn’t work for everyone, and researchers have increasingly turned their attention to understanding why.
-
Mapping Genetic Diversity of Lung Tumors Over Time May Lead to More Effective Therapies
Researchers have figured out how to assemble genetic profiles of individual lung cancer cells obtained from patients at different times during the course of their treatment.
-
Largest-Ever Study of Prostate Cancer Genomics in Black Men IDs Potential Targets for Precision Therapies
None of the individual tumor genetic differences that were identified are likely to explain significant differences in health outcomes or to prevent Black Americans from benefiting from a new generation of precision prostate cancer therapies, researchers say, as long as the therapies are applied equitably.
-
New Model of Breast Cancer’s Causes Developed by UCSF-led Team
A new model of the causes of breast cancer, created by a team led by researchers at UCSF, Genentech and Stanford University, is designed to capture the complex interrelationships between dozens of primary and secondary breast cancer causes and stimulate further research.
-
Recombinant Antibody Network Partners with Bristol Myers Squibb to Develop Novel Therapies
Under a new agreement, Celgene will further invest in the RAN’s state-of-the-art antibody engineering program to expand target discovery from oncology and immunology to include neurology.
-
UCSF, St. Jude Identify Key Culprit Driving Treatment Resistance in Deadly Immune Disorder
The finding could offer additional insights into other immune conditions, including a type of childhood leukemia and the severe inflammation response in some children with COVID-19.
-
Tumors Disrupt the Immune System Throughout the Body
Depending on a cancer’s tissue of origin, tumors cause widespread and variable disruption of the immune system throughout the body, not just at the primary tumor site.
-
UCSF Cancer Researchers Present New Advances at ASCO 2020
Cancer specialists from UCSF will present new research findings at the annual scientific program of the American Society of Clinical Oncology, the world’s largest clinical cancer research meeting.
-
Flipping A Genetic Switch on Cells Lets Researchers Boost or Suppress Immune Responses
Cancer and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, might not seem to have much in common, but some researchers now are pinning hopes on the same immune system cell –
-
CRISPR-Based ‘Discovery Engine’ for New Cell Therapies to Advance Cancer Treatments
UCSF researchers now have reported a new method to design and test cell therapies, one they expect will speed the development of new life-saving treatments not only for cancer, but for other diseases, too.
-
Brain Tumor Surgery that Pushes Boundaries Boosts Patients Survival
Survival may more than double for adults with glioblastoma, if neurosurgeons remove the surrounding tissue as aggressively as they remove the cancerous core of the tumor.
-
Study Finds Talcum Powder Not Likely A Risk For Ovarian Cancer