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UCSF researchers have devised a CRISPR-based system called SLICE, which will allow scientists to rapidly assess the function of each and every gene in “primary” immune cells.
UCSF demonstrates that cancer is a clever engineer, capable of constructing entirely new disease-promoting networks out of raw materials readily available in the cell.
The Quantitative Biosciences Institute attracts investigators on the basis of the tools and techniques they employ, rather than the diseases they study.
Seven UCSF research subject areas were ranked in the top 10 globally by US News & World Report.
UCSF researchers discovered a gene that plays an essential role in noise-induced deafness.
UCSF scientists are working to understand how concussions cause long-term cognitive damage – and how they might be treated.
These results confirm that the HPV virus causes head and neck cancer by inactivating the same proteins that are mutated in smoking-induced cancer.
A collaboration between three labs at UCSF has resulted in an unprecedented look at a member of a vital and ubiquitous class of proteins called integrins.
UCSF scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
Although CRISPR has made headlines as a powerful system for editing genes, it actually evolved as way for bacteria to defend themselves against infection by viruses.
In an achievement that has significant implications for research, medicine, and industry, UCSF scientists have genetically reprogrammed human immune cells without using viruses to insert DNA
Experiments using parasitic worms in the mouse gut have revealed a surprising new form of wound repair, a finding that could help scientists develop ways to enhance the body’s natural healing abilities.
A so-called “jumping gene” that researchers long considered either genetic junk or a pernicious parasite is actually a critical regulator of the first stages of embryonic development.
Scientists have used ultra-high-resolution cryo–electron microscopy to capture the most detailed portrait ever of an opioid drug triggering the biochemical signaling cascade that gives it its power.
The journey from discovering and developing effective, precise medications to using them correctly and safely in patients is hardly fast and easy. Nor is it a straight shot. Scientists in the UCSF School of Pharmacy are challenging the status quo every step of the way.
UCSF researchers have discovered that shark and skate electrosensory systems have distinct specializations that match how the animals use their electrical sense in the wild.
Researchers have demonstrated the ability to program groups of individual cells to self-organize into multi-layered structures reminiscent of simple organisms or the first stages of embryonic development.
A UCSF researcher is among scientists who discovered the specific bacterial enzyme found in the human gut that can render a common heart drug ineffective.
Study led by UCSF scientists shows that brain cells react differently to opioid substances created inside the body than they do to purely synthetic opioid drugs.
UC San Francisco researchers have discovered a promising new line of attack against lethal, treatment-resistant prostate cancer.
A new study finds that a common cancer-causing mutation in a GTPase called Gαs subverts the model for this type of growth switch in cancer.
UCSF researchers have shown that an experimental brain boosting drug, ISRIB, acts like a molecular staple, pinning together parts of a much larger protein involved in cellular stress.
UCSF scientists have invented a technique that lets them precisely and reversibly disrupt the action of specific cellular proteins at a microscopic scale by making them split apart when illuminated with blue light.
UCSF have taken the first step toward a comprehensive atlas of gene expression in cells across the developing human brain.
Peter Walter, PhD, professor of biochemistry and biophysics at UCSF, has been named winner of a 2018 Breakthrough Prize in Life Sciences, for his research on a biological mechanism that normally protects cells, but can cause disease if not functioning properly.
UCSF researchers are leading several initiatives that aim to see how dozens of seemingly unrelated genes and proteins involved in a disease are in fact all part the same interconnected biological pathway.
UCSF has ranked in the top 10 for seven specialties in 2017 Best Global Universities rankings released Tuesday by U.S. News & World Report.
UCSF researchers have identified a molecular signature in tissue adjacent to tumors in eight of the most common cancers that suggests they are all using the same mechanism to remodel normal tissue and spread.
Newly developed microscopy techniques have allowed UC San Francisco researchers to observe white blood cells in action in unprecedented detail.
Research team led by University of California scientists has used a modified version of the gene-editing technique CRISPR to find enhancers by prompting them into action.
