“CAR Pooling” Screens Identify Most Effective Cancer Immunotherapy Cells
A new method of comparing massive numbers of CAR-T cells can determine which is most effective and long-lasting against cancer.
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UCSF Study Sheds Light on the Reasons Behind Sex Differences in Myocarditis
Immune checkpoint inhibitors (ICIs) used in cancer care can cause myocarditis, a potentially fatal side effect, and it appears that the adverse cardiac effects may disproportionally impact female patients.
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Machine Learning Enables Diagnosis of Sepsis, the Elusive Global Killer
A new diagnostic method that applies machine learning to advanced genomics data from both microbe and host to identify and predict sepsis cases was developed by researchers at UCSF, the Chan Zuckerberg Initiative, and CZ Biohub.
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Omicron’s Evolution and the New Bivalent COVID-19 Booster
Last month new “bivalent” booster vaccines made by Moderna and Pfizer became available that protect against currently circulating Omicron variants as well as earlier strains of the SARS-CoV-2 virus that causes COVID-19. This Q&A features Joel Ernst, MD, a UCSF professor of medicine whose research aims to understand how pathogens evade the immune system.
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Drug Turns Cancer Gene Into ‘Eat Me’ Flag for Immune System
A new therapy pulls forward a mutated version of the KRAS protein to help the immune system recognize and destroy cancer cells.
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Research Reveals Mechanisms at Work in Progression of Pancreatic Cysts to Pancreatic Cancer
UCSF-led research outlines the comprehensive immune landscape and microbiome of pancreatic cysts as they progress from benign cysts to pancreatic cancer. Their findings could reveal the mechanism of neoplastic progression and provide targets for immunotherapy to inhibit progression or treat invasive disease.
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A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), lets scientists introduce especially long DNA sequences to precise locations in the genomes of cells at remarkably high efficiencies without the viral delivery systems that have traditionally been used to carry DNA into cells.
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Giving Immunotherapy Cells Resilience to Pass the ‘Stress Test’
T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.
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Can Monkeypox Spread Through the Air or on Surfaces? Here’s What To Know
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Have New COVID Variants Changed What We Know About Surface Transmission?
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Scientists Map Networks of Disease-Associated Immune Genes
A new "subway map" of immune networks connects gene variation to risk for autoimmune disease.
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In Colitis Patients, Skin Conditions May Originate in the Gut
A new UCSF study reveals how gut inflammation can disrupt not only the digestive system, but also the skin. It’s a tale in which the main players are specialized immune cells and the bacterial communities — called microbiomes — that dwell within the gut and skin.
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FDA Advisors Approve Pfizer, Moderna Vaccines for Young Children
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What’s Changed and What Hasn’t Since the End of California’s COVID Lockdown
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Why Do Some People Never Test Positive for COVID, Even After Exposure and Symptoms?
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How Dangerous Is Mpox? UCSF’s Seth Blumberg Explains
Seth Blumberg, MD, PhD, an assistant professor of medicine, is clinical specialist in infectious disease, including Mpox. He offers insight in the recent outbreak in a Q&A.
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UCSF Readying Itself to Tackle Future Pandemics
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Evidence Mounts for Need To Study Pfizer’s Paxlovid for Long COVID - Researchers Say
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Vaccine-derived Polio Is on the Rise. A New Vaccine Aims To Stop the Spread
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The World Health Organization Approves a New Polio Vaccine for Emergency Use
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How Obesity Can Rewire the Immune System and the Response to Immunotherapy – and How to Change That
For the new study published in the journal Nature on March 30, 2022, researchers at Gladstone Institutes, the Salk Institute for Biological Studies, and UC San Francisco (UCSF) teamed up. Their findings, shed light on how obesity can change the immune system and, potentially, how clinicians might be able to better treat allergies and asthma in obese people.
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Evidence Grows That Vaccines Lower the Risk of Getting Long COVID
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What Does a Faint Line on Your COVID Antigen Test Mean?
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Seasonal Allergies in the Bay Area May Get Worse – And Affect More People. Here’s Why
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How UCSF’s Data Science Team Took on COVID
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Studies Reveal New ‘Stealth’ Omicron Variant Is 30% More Transmissible. Should California Be Worried?
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UCSF Gene Therapy for Deadly Mutation Fast-Tracked for FDA Review
A new fast-track review for UCSF gene therapy could help more kids with deadly Artemis-SCID disease get life-saving treatment sooner.
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Immune Cells Leave Fingerprints on Tumors Metastasized to the Brain, Offering Clues to Future Therapies
Using data from over 100,000 malignant and non-malignant cells from 15 human brain metastases, UCSF researchers have revealed two functional archetypes of metastatic cells across 7 different types of brain tumors, each containing both immune and non-immune cell types.
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Cerebrospinal Fluid Offers Clues to Post-COVID ‘Brain Fog’
Many patients with COVID-19 develop brain fog and other cognitive symptoms months later. Their cerebrospinal fluid may hold clues to why this is happening.
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Sorting Cancers by ‘Immune Archetypes’ May Offer New Approach For Precision Immunotherapies
UCSF researchers found that cancers from different parts of the body are immunologically similar to one another. They described 12 classes of "immune archetypes" to classify cancer tumors, which can provide unique strategies for enhancing patients’ choice of cancer immunotherapies.
