Drug Target for Triple-Negative Breast Cancer Found in New Study
A team of researchers led by UCSF scientists has identified a new drug target for triple-negative breast cancer.
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Some Breast Cancer Patients With Low Genetic Risk Could Skip Chemotherapy, Study Finds
Early-stage breast cancer patients whose tumors carry genetic markers associated with a low risk of disease recurrence may not need to undergo chemotherapy, suggests a new study that employed a test devised by a UCSF researcher.
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Frequency of Breast Cancer Screening is Best Guided by Both Risk, Breast Density, Says Study
The ideal interval for breast cancer screening depends on combined assessments of each woman’s breast cancer risk and her breast density, according to a new study led by UCSF and University of Wisconsin researchers.
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Covert Inflammation May Trigger Many Forms of Cancer
A previously unidentifiable type of low-grade inflammation may explain why common anti-inflammatory drugs such as aspirin have shown promise against some types of cancer – even when patients don’t display typical signs of inflammation.
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Triple-Negative Breast Cancers Depend on Fat as Fuel, Research Shows
The most intractable common form of breast cancer might in most cases be treatable by drugs that target fat metabolism, according to UCSF researchers.
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For Breast Cancer Patients, Never Too Late To Quit Smoking
Documenting that it’s never too late to quit smoking, a large study of breast cancer survivors has found that those who quit smoking after their diagnosis had a 33% lower risk of death as a result of breast cancer than those who continued to smoke.
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Metastatic Breast Cancer Cells Turn On Stem Cell Genes
UCSF scientists describe capturing and studying individual metastatic cells from human breast cancer tumors implanted into mice as the cells escaped into the blood stream and began to form tumors elsewhere in the body.
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Building Human Breast Tissue, Cell by Cell
Zev Gartner is working to building a fully functioning 3-D human breast tissue that will allow him to test potential cancer therapies, an innovation that's earned him a spot among Popular Science's "Brilliant 10" this year.
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Mammary Gland Is Shaped by Adaptive Immune System During Development
UCSF researchers have discovered that the adaptive immune system plays an active role in guiding the normal development of mammary glands, the only organs that develop predominantly after birth, beginning at puberty.
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Tool Boosts Accuracy in Assessing Breast Cancer Risk
A national risk model that gauges a woman’s chance of developing breast cancer has been refined to give a more accurate assessment.
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Angiogenesis Inhibitors Undermined by Immune Cells, Says Study
A team led by UCSF scientists has discovered a possible reason why angiogenesis inhibitors often work in the short term but usually become ineffective within months, one that could lead to a way to prevent cancer relapse.
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Three UCSF Pioneers to Appear in PBS Cancer Documentary
UCSF Chancellor and Professor Emeritus J. Michael Bishop, MD, Professor Emeritus Harold Varmus, MD, and Chancellor and Professor Emeritus Susan Desmond-Hellmann, MD, MPH, will be highlighted for their pioneering work on cancer in the Ken Burns-produced PBS documentary series “Cancer: The Emperor of All Maladies,” which airs March 30-April 1, 2015.
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Genetic Variant Protects Some Latina Women from Breast Cancer
An international research collaboration led by UCSF researchers has identified a genetic variant common in Latina women that protects against breast cancer.
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Human Cancer Prognosis Is Related to Newly Identified Immune Cell
A newly discovered population of immune cells in tumors is associated with less severe cancer outcomes in humans, and may have therapeutic potential, according to a new UCSF study.
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Bone Drugs May Not Protect Osteoporotic Women from Breast Cancer
Osteoporosis drugs known as bisphosphonates may not protect women from breast cancer as had been thought, according to a new study led by researchers at UCSF.
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Cancer Categories Recast in Largest-Ever Genomic Study
New research partly led by UCSF-affiliated scientists suggests that one in 10 cancer patients would be more accurately diagnosed if their tumors were defined by cellular and molecular criteria rather than by the tissues in which they originated.
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New Breast Cancer Results Illustrate Promise and Potential of I-SPY 2 Trial
In an innovative clinical trial led by UCSF, the experimental drug neratinib along with standard chemotherapy was found to be a beneficial treatment for some women with newly diagnosed, high-risk breast cancer.
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Experts Question Routine Mammograms in Elderly
Doctors should focus on life expectancy when deciding whether to order mammograms for their oldest female patients, since the harms of screening likely outweigh the benefits unless women are expected to live at least another decade, according to a review of the scientific literature by experts at UCSF and Harvard medical schools.
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Mechanical Forces Driving Breast Cancer Lead to Key Molecular Discovery
The stiffening of breast tissue in breast-cancer development points to a new way to distinguish a type of breast cancer with a poor prognosis from a related, but often less deadly type, UCSF researchers have found in a new study.
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Scientist Identifies Triple-Negative Breast Cancer Target for Drug Development
Often deadly “triple-negative” breast cancers might be effectively treated in many cases with a drug that targets a previously unknown vulnerability in the tumors, UCSF reports.
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Pain Studies Enhance Precision Medicine
A team of researchers at UCSF is incorporating genomics into a broad group of potential factors that can help clinicians better understand which patients are at greatest risk for persistent postsurgical pain and how to better prevent or treat it.
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Cancer Drugs: Better, Cheaper
<p>The U.S. Food and Drug Administration is issuing new recommendations for breast cancer trials that are based in part on groundbreaking, national breast cancer research led by UCSF.</p>
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Some Breast Cancer Spread May Be Triggered By Targetable Protein, Study Shows
Scientists from the University of Helsinki, Finland, and UCSF have identified a cleaver-wielding protein that frees some tumor cells, allowing them to further misbehave. The discovery points to a new target for therapy.
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High Rate of False-Positives with Annual Mammogram
During a decade of receiving mammograms, more than half of cancer-free women will be among those summoned back for more testing because of false-positive results, and about one in 12 will be referred for a biopsy.
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$6.5 Million Study Targets High Breast Cancer Deaths in Black Women
<p>African American women have lower breast cancer survival rates than white women and University of California, San Francisco (UCSF) scientists are studying why – as well as how to increase their life spans.</p>
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US Launches Novel Clinical Trial to Rapidly Screen Promising Drugs for Breast Cancer Patients
Taking an innovative path toward personalized medicine, scientists for the first time will be able to eliminate – at an early point in a clinical trial — experimental drugs that show poor efficacy, dramatically shortening the time it takes to get the right medication to the right patient with breast cancer.
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Overweight women at increased risk of advanced breast cancer
A nationwide study of over 280,000 women showed that postmenopausal women who are overweight or obese have advanced breast cancer at significantly higher rates than women of normal weight or less than normal weight.
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Puberty, Obesity, Environment and Breast Cancer