UCSF Researchers Discover How Vascular Cells Develop in Prenatal Brain
UCSF has revealed how blood vessel cells develop in the prenatal human brain, paving the way to fully understand the role of these cells in healthy brain development and disease.
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A Drug Based on LSD Appears to Treat Depression in Mice Without the Psychedelic Trip
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Cardiovascular Health Technology to Be Fast-Tracked through Innovative Fellowship Program
The new UCSF Rosenman Institute BUILD™ Heart Health program is designed as an 11-month cycle of fully funded fellowships aimed at training the next generation of health technology entrepreneurs.
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LSD-Like Molecules Counter Depression Without the Trip
Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks.
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Landmark Study of Biomarker Data May Enable Better Treatment for Early Onset Dementia
UCSF researchers Adam Staffaroni, PhD, and Adam Boxer, MD, PhD developed models of clinical and biomarker dynamics to determine the temporal sequence of biomarker and clinical changes in f-FTD before disease progression begins.
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Why Overdose Deaths Skyrocketed After Opioid Prescriptions Dropped
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UCSF Develops First of Its Kind Robotic Surgery Trial in Partnership with FDA
UCSF Health is recruiting patients for the only FDA-approved study of the use of single port robotic technology for colorectal surgery in the United States.
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Dozens of Gut Bacteria Associated with Multiple Sclerosis
Researchers have found significant differences between the gut bacteria profiles of multiple sclerosis (MS) patients and healthy individuals, showing new pathways for potential treatment.
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Drug Turns Cancer Gene Into ‘Eat Me’ Flag for Immune System
A new therapy pulls forward a mutated version of the KRAS protein to help the immune system recognize and destroy cancer cells.
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New Study Finds ‘Widespread Exposure’ to Cancer-Causing Chemicals During Pregnancy
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Neighborhood Characteristics Affect How Often a Child Visits Emergency Department
Children living in neighborhoods with greater hardships, such as substandard housing or high pollution, are more likely to use emergency departments, including for complaints that could be managed by their pediatricians, a new study led by UCSF Benioff Children’s Hospitals found.
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Exercise Rates Still Haven’t Recovered From Pandemic, Global Study Shows
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Physical Activity May Still Not Match Pre-Covid 19 Pandemic Levels
A UCSF study found that step counts, a measure of physical activity, were markedly lower early in the COVID-19 pandemic than pre-pandemic and remained lower on average in the two years following the onset of the global pandemic.
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Research Reveals Mechanisms at Work in Progression of Pancreatic Cysts to Pancreatic Cancer
UCSF-led research outlines the comprehensive immune landscape and microbiome of pancreatic cysts as they progress from benign cysts to pancreatic cancer. Their findings could reveal the mechanism of neoplastic progression and provide targets for immunotherapy to inhibit progression or treat invasive disease.
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Pregnant Women Exposed to Cancer-Causing Chemicals in Dishware, Hair Coloring, Plastics, and Pesticides
Pregnant women in the U.S. are being exposed to chemicals like melamine, cyanuric acid, and aromatic amines that can increase the risk of cancer and harm child development, according to a study from researchers at UCSF and Johns Hopkins Bloomberg School of Public Health.
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Just How Bad for Health Is Homelessness? Ucsf Study Finds Dire Outcomes for Oakland’s Older Population
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Older Homeless People Are At Great Risk of Dying
The study, funded by the National Institute on Aging, recruited people who were 50 and older and homeless, and followed them for a median of 4.5 years. By interviewing people every six months about their health and housing status, researchers were able to examine how things like regaining housing, using drugs, and having various chronic conditions, such as diabetes, affected their risk of dying.
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Half of Moms of Kids with Autism Have High Depressive Symptoms
About 50% of all mothers of children with autism spectrum disorder (ASD) had elevated levels of depressive symptoms over 18 months, while rates were much lower (6% to 13.6%) for mothers with neurotypical children in the same period, UCSF researchers report in a new study.
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Ethnicity, Poverty, Low Community Involvement Linked to Lasting Loneliness
Most people are at risk for periodic loneliness, but for midlife and older adults who identify as Hispanic/Latinx, or who live in poverty, loneliness may be less likely to resolve over time.
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Eye Movements in REM Sleep Mimic Gazes in the Dream World
When our eyes move during REM sleep, we’re gazing at things in the dream world our brains have created, according to a new study by UCSF researchers. The findings shed light not only into how we dream, but also into how our imaginations work.
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A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), lets scientists introduce especially long DNA sequences to precise locations in the genomes of cells at remarkably high efficiencies without the viral delivery systems that have traditionally been used to carry DNA into cells.
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A New Test for an Old Theory About Dreams
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New Pediatric Tumor Identifications Could Help Predict Chemo Response
A new UCSF study sheds light on the diversity within the most common type of pediatric liver tumor and suggests a way forward for more precise chemotherapy treatment.
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Giving Immunotherapy Cells Resilience to Pass the ‘Stress Test’
T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.
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Routine Depression Screening May Capture Underdiagnosed Patient Populations
According to a new UCSF study, screening for depression at the primary care level could dramatically increase the likelihood of treatment for those who are traditionally undertreated — racial and ethnic minority individuals, older adults, those with limited English proficiency and men.
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For Checking Blood Pressure at Home, Basic Cuffs Are Just as Good
A new national study led by UCSF found that more sophisticated devices that pair with smartphones don’t lead to better blood pressure control than home-use blood pressure cuffs.
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Are You Just Distracted or Is It Adult ADHD?
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San Francisco, San Mateo Co. Residents Urged to Share Long COVID Stories
UCSF, San Francisco Department of Public Health (SFDPH) and San Mateo County Health (SMC Health) are partnering with local community groups to learn about long COVID. Their project, Let’s Figure Out Long COVID – Tell Us Your Story, Bay Area, will call local residents of all ethnicities and backgrounds who previously had COVID.
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Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease
The discovery of how to shift damaged brain cells from a diseased state into a healthy one poses a potential new path to treating Alzheimer’s and other forms of dementia, according to a new study from UCSF researchers.
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New Research Finds Blood Tests Can Predict Severe Outcomes of Brain Injury