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In an innovative clinical trial led by UCSF, the experimental drug neratinib along with standard chemotherapy was found to be a beneficial treatment for some women with newly diagnosed, high-risk breast cancer.
Doctors should focus on life expectancy when deciding whether to order mammograms for their oldest female patients, since the harms of screening likely outweigh the benefits unless women are expected to live at least another decade, according to a review of the scientific literature by experts at UCSF and Harvard medical schools.
The stiffening of breast tissue in breast-cancer development points to a new way to distinguish a type of breast cancer with a poor prognosis from a related, but often less deadly type, UCSF researchers have found in a new study.
Researchers are harnessing the power of the body's natural defenses to fight deadly cancers, and the treatment appears to be powerful, effective and long-lasting.
UCSF scientist Valerie Weaver, PhD, received a $1.2 million award from the California Institute for Regenerative Medicine (CIRM) for research that explores the transformation of stem cells into specialized cell types.
UCSF and Quest Diagnostics, the world's leading provider of diagnostic information services, have formed a collaboration to accelerate the translation of biomedical research into advanced diagnostics in the field of precision medicine.
Experts across UCSF weigh in on what some of 2014's top trends are in research and patient care.
A team led by scientists from UCSF has discovered that recurrent gliomas may have genetic profiles that are markedly different from those of the initial tumors that spawned them.
A UCSF investigator has won an eight-year grant from the National Cancer Institute for a major investigation into anal cancer, a debilitating and sometimes fatal disease largely concentrated among people with HIV.
The protein in cells that most often drives the development of cancers has eluded scientists’ efforts to block it for three decades — until now.
Precision Medicine Pillar No. 2: Basic Discovery. The long path to developing potent new treatments often starts with an observation in the lab that then leads to a question about a fundamental life process.
A UCSF-led team of scientists has discovered that a gene mutation found in some bladder cancers is indicative of low-risk tumors that are unlikely to recur or progress after surgery.
The way cells divide to form new cells – to support growth, to repair damaged tissues, or simply to maintain our healthy adult functioning – is controlled in previously unsuspected ways, UCSF researchers have discovered.
UCSF will receive a five year, $20 million grant as part of a first-of-its-kind tobacco science regulatory program by the U.S. Food and Drug Administration and the National Institutes of Health.
A natural form of sugar could offer a noninvasive way to precisely image tumors and determine whether cancer medication is effective using new technology developed at UCSF in collaboration with GE Healthcare.
UCSF’s Emmanuelle Passegué, an expert on how the blood system arises during development, recently led a study in which researchers discovered how leukemia, a blood cancer, can gain a stronghold in bone marrow and inhibit the development of normal immune cells.
Stem-cell researchers at UCSF have found a key role for a protein called BMI1 that may help scientists direct the development of tissues to replace damaged organs in the human body.
UCSF researchers have found a way to knock down cancers caused by a tumor-driving protein called “myc,” paving the way for patients with myc-driven cancers to enroll in clinical trials for experimental treatments.
Aspirin is known to lower risk for some cancers, and a new UCSF-led study points to a possible explanation, with the discovery that aspirin slows the accumulation of DNA mutations in abnormal cells in at least one pre-cancerous condition.
Smoking tobacco through a hookah is gaining popularity among the college crowd, but UCSF researchers have found that hookah smoke contains a different – but still harmful – mix of toxins than cigarettes.
A Phase 2 clinical trial testing a new protocol for treating a relatively rare form of brain cancer, primary CNS lymphoma, may change the standard of care for this disease, according to UCSF doctors who led the research.
Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, UCSF researchers have discovered.
<p>A team of researchers from UCSF and the University of Pennsylvania has uncovered how a normal biological mechanism called the “unfolded protein response,” goes awry in human lymphoma – work that may lead to the development of specific drugs to fight different forms of cancer.</p>
A 20-year study following 110,645 workers who helped clean up after the 1986 Chernobyl nuclear power plant accident shows that the workers share a significant increased risk of developing leukemia.
A new molecular test developed by doctors at UCSF may give doctors the ability to better predict post-operative early-stage lung cancer mortality.