UCSF Researchers Uncover New Pathway for Molecular Cancer Drug Therapies
Researchers have discovered a cellular uptake pathway for larger molecules that delivers cell-permeable drugs efficiently.
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Cellular “Glue” to Regenerate Tissues, Heal Wounds, Regrow Nerves
Researchers have engineered molecules that act like “cellular glue,” a major step toward building tissues and organs.
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Myocarditis in Cancer Patients Is Driven by Specific Immune Cells
Researchers have identified specific immune cells that drive deadly heart inflammation in a small fraction of patients treated with powerful cancer immunotherapy drugs.
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Fatty Liver Linked to Survival in E. Coli Infection
Scientists at UCSF have developed a new way of looking at sex-biased diseases that is rooted in evolutionary biology.
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Marijuana, Meth, Cocaine and Opiate Use are Linked to Atrial Fibrillation
A new UCSF study researchers of more than 23 million people concludes that some commonly used and abused drugs pose previously unidentified risks for the development of atrial fibrillation (AF), a potentially deadly heart-rhythm disorder.
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Marijuana Use Linked to Atrial Fibrillation in New UCSF Study
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Single-Celled Organism Uses Internal ‘Computer’ to Walk
The single-celled protozoan Euplotes eurystomus achieves a scurrying walk by coordinate its microscopic uses a simple, mechanical computer instead of a brain like most animals, UCSF researchers found.
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Non-Opioid Compounds Squelch Pain Without Sedation
A newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco.
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UCSF Researchers Discover How Vascular Cells Develop in Prenatal Brain
UCSF has revealed how blood vessel cells develop in the prenatal human brain, paving the way to fully understand the role of these cells in healthy brain development and disease.
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Pregnant Women Exposed to Cancer-Causing Chemicals in Dishware, Hair Coloring, Plastics, and Pesticides
Pregnant women in the U.S. are being exposed to chemicals like melamine, cyanuric acid, and aromatic amines that can increase the risk of cancer and harm child development, according to a study from researchers at UCSF and Johns Hopkins Bloomberg School of Public Health.
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A.I. Predicts the Shape of Nearly Every Protein Known to Science
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The Nobel-Winning Discoveries Illuminating How We Sense the World
How David Julius and Ardem Patapoutian found the molecules in our bodies that sense heat, cold, touch, and pain – and transformed sensory neuroscience.
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UCSF Cancer Specialists to Present Clinical Findings at Major Conference
The latest advances in cancer care and research will be showcased at the annual American Society of Clinical Oncology (ASCO) Annual Meeting, the world’s largest clinical cancer meeting.
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Solving the Mystery of a Stubborn – and Common – Cancer Gene
Mark Moasser, MD, has sorted out why HER2, the protein driving 1 in 5 breast cancers, is so hard to drug. He explains how the findings correct a naive way of envisioning how HER2 is shaped and how it works.
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Immune Cells Leave Fingerprints on Tumors Metastasized to the Brain, Offering Clues to Future Therapies
Using data from over 100,000 malignant and non-malignant cells from 15 human brain metastases, UCSF researchers have revealed two functional archetypes of metastatic cells across 7 different types of brain tumors, each containing both immune and non-immune cell types.
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International Breast Cancer Conference Features UCSF Health Experts
Helen Diller Family Cancer Research Building Experts from UCSF Health will present new research and clinical findings at the annual San Antonio Breast Cancer Symposium, the world’s largest and most
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Looking to the Cell’s Power Generators for Clues to Depression
Hoping to discover a new approach to treating depression, UCSF researchers looked at mitochondrial proteins and found that people with untreated depression have significantly lower levels of these proteins. New hypotheses emerge about the relationship between depression and the function of the brain’s energy-hungry neurons.
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UCSF Rises in US News Global Universities Rankings for 2022
UCSF’s research has been ranked among the top in the world, according to the latest U.S. News & World Report’s Best Global Universities 2022 rankings.
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How Cells Multitask: The Magic of Molecular Switches
Researchers at UCSF’s Quantitative Biosciences Institute (QBI) have observed how molecular switches regulate many different biological processes simultaneously. Their findings may shed light on how disease mutations operate, offering new ways to target malfunctioning switches and prevent illness.
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Scientists Map Brain Circuit that Drives Activity in Fertile Females
A team of UCSF scientists have identified the specific neurons and signaling pathway that make sexually receptive females of many species more active at the time of ovulation.
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This Molecule Could Be the Key to Understanding Why Concussions Have Such Long-Term Effects
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Here’s Why Poisonous Animals Don’t Poison Themselves
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Poison Frogs, Birds, Hold Clues to Antidotes for Deadly Toxins
A team of researchers at have uncovered some intriguing clues in the mystery of how some poison birds and frogs evade their own toxins.
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Beyond CAR-T: New Frontiers in Living Cell Therapies
Taking a page from computer engineers, biologists are trying their hands at programming cells – by building DNA circuits to guide their protein-making machinery and behavior.
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Microbiome Medicine: Scientists Harness the Body’s ‘Bugs’ to Treat Asthma, MS and More
Plenty of probiotic yogurts, pickles and kombuchas claim to boost our digestive health with armies of microbes, but some scientists have more ambitious therapeutic plans for the “bugs” that colonize us. They hope to leverage these microbes as living therapeutics for a range of health conditions, including ulcerative colitis, multiple sclerosis, eczema and asthma.
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Mutation in Highly Infectious Alpha Variant May Help Coronavirus Evade Immune System
The B.1.1.7 coronavirus variant—also known as Alpha—may be more infectious because it contains mutations that make it better adapted to foil the innate immune system, at least for long enough to allow the virus to replicate and potentially find new hosts, according to a new study.
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The Case of the Recurring Fever
An elderly man had symptoms no one could explain – until Amy Berger, MD, PhD, and her team investigated.
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Your Immune System Could Turn COVID-19 Deadly
Hidden autoimmunity may explain how the coronavirus wreaks such widespread and unpredictable harm.
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TED Talk: “Can We Create Vaccines that Mutate and Spread?”
The viruses that cause polio and COVID-19 mutate, but treatments for the diseases don’t. For over 20 years, UCSF and Gladstone Institutes scientist Leor Weinberger, PhD, has been thinking of ways to make vaccines work more efficiently by being adaptive, rather than static.
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Space Travel Weakens Our Immune Systems – Now Scientists May Know Why
Scientists now have shown that the weakening of an astronaut’s immune system during space travel is likely due in part to abnormal activation of immune cells called T regulator cells.
