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A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), lets scientists introduce especially long DNA sequences to precise locations in the genomes of cells at remarkably high efficiencies without the viral delivery systems that have traditionally been used to carry DNA into cells.
UCSF Survey Finds Vast Majority Comfortable with Campus Climate
A campuswide survey of members of the UCSF community finds that respondents are generally positive about the University’s working and learning environment overall with 70% indicating that they feel either “comfortable” or “very comfortable” while 11% feel “uncomfortable” or “very uncomfortable.”
New Mission Bay Mural Sends Message of Peace
A newly installed mural titled “Peace Piece” stretches over seven stories of the parking garage at the corner of Third Street and Mariposa on UCSF’s Mission Bay campus. Created by San Francisco artist Kota Ezawa, it is an extension of the Michael J. Bishop Art Collection at Mission Bay.
New Pediatric Tumor Identifications Could Help Predict Chemo Response
A new UCSF study sheds light on the diversity within the most common type of pediatric liver tumor and suggests a way forward for more precise chemotherapy treatment.
Giving Immunotherapy Cells Resilience to Pass the ‘Stress Test’
T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.
Routine Depression Screening May Capture Underdiagnosed Patient Populations
According to a new UCSF study, screening for depression at the primary care level could dramatically increase the likelihood of treatment for those who are traditionally undertreated — racial and ethnic minority individuals, older adults, those with limited English proficiency and men.
For Checking Blood Pressure at Home, Basic Cuffs Are Just as Good
A new national study led by UCSF found that more sophisticated devices that pair with smartphones don’t lead to better blood pressure control than home-use blood pressure cuffs.
Abortion Ban May Increase Risk of Death for Pregnant Women with Cancer
The repercussions of overturning Roe v. Wade – and the failure of the Supreme Court to provide any guidance on exceptions related to the life and health of the mother – are potentially catastrophic for women who face a life-threating diagnosis of pregnancy associated cancers (PAC).
San Francisco, San Mateo Co. Residents Urged to Share Long COVID Stories
UCSF, San Francisco Department of Public Health (SFDPH) and San Mateo County Health (SMC Health) are partnering with local community groups to learn about long COVID. Their project, Let’s Figure Out Long COVID – Tell Us Your Story, Bay Area, will call local residents of all ethnicities and backgrounds who previously had COVID.
Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease
The discovery of how to shift damaged brain cells from a diseased state into a healthy one poses a potential new path to treating Alzheimer’s and other forms of dementia, according to a new study from UCSF researchers.
